Hemophilia-ChrisD

Hemophilia **Description: ** Hemophilia is a rare blood disorder in which the blood does not clot, or the blood may take a long period of time to clot. In this disorder it is easy to receive a small cut but have large effect.

**Inheritance: ** This blood disorder is inherited from a x linked recessive pattern. The x chromosome can only carry this. In order to receive this thought, a male must have a abnormal gene x and the female must have a pair of abnormal x chromosomes. Although it may seem like it is easier for a female it is a fact that usually it happens to men and it is rarely expressed in women due to the fact that a male has a chromosome y and only one x it leaves them more vulnerable.

**Symptoms: ** Usually Children do not show any symptoms of this disorder, the only way to really tell is if they have received a cut and start to over excessively bleed from where the cut or wound appears.

**Daily Life: ** The daily life contains much precaution of what you are doing and to be aware of your surrounding. For a child most may not participate in any sport do to the fact they may receive easy internal or external bleeding. For much of the adults with this disorder, driving and normal task like that must be take with much precaution. **Diagnosis: ** The diagnoses happens when the majority of recessive traits are expressed in the x chromosome. This disorder will usually run in the family weather or not you’re a carrier or not at one point in which one has a boy it is more likely to be expressed.

**Treatment: ** Hemophilia is treated by injection clotting factor VII or clotting factor IX into the vein affecting clots in area in which it’s missing or low. Most of the injection has been tested on other blood samples before. Sometime they inject

**Research: ** The new research is what about what they want to replace the defective gene with. So far they have been able to replace a bad gene with a good gene and it has been done a couple of time successfully. The only way really to do it though is with a vector. Even though they are harmless sometimes when its used it gene therapy there are malfunctions.

**Pedigree Chart:**

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