HEMOPHILIA+DISEASE-PRERAKP

Hemophilia Disease **Description: ** The normal mechanism for blood clotting is the complex series of events involving the interaction of the injury blood vessels, blood cells and over 20 different proteins which also circulate in the blood. When a blood vessel is injured in a way that causes bleeding, platelets collect over the injured area, and form a temporary plug to prevent further bleeding.

**Inheritance: ** The genes for the clotting factors are located on the x chromosome. Therefore, hemophilia is an x linked disorder. Hemophilia is caused when a defective X chromosome gene is inherited. In such type of inheritance, there is no direct transfer of the affected genes from father to son or mother to daughter. Instead, the affected genes are transferred from the father to his daughter. The daughter is not affected by genes but remains the carrier.

**Symptoms: ** The most common symptom of hemophilia is excessive, uncontrollable bleeding because of missing or low-level clotting factor in the blood. The extend of bleeding depends on the type of severity of the hemophilia. Males who have serve hemophilia may bleed heavily after circumcision. Bleeding can occur on the body’s surface or inside the body.

**Daily Life: **

Daily life for the person with hemophilia is not so good. Someone with hemophilia can’t live so much if they start bleeding one time.

**Diagnosis: ** If hemophilia is suspected, or if you appear to have a bleeding problem, your doctor will take your family medical histories. This will reveal whether you or anyone in your family has a history of frequent or heavy bleeding and bruising.

**Treatment: ** The main treatment for hemophilia is called replacement therapy. Concentrates of clotting factor V111 (for hemophilia A) or clotting factor 1X (for hemophilia B) are slowly dripped in or injected into a vein. These infusions help replace the clotting factor that’s missing or law. Complications of replacement therapy include:- · Developing antibodies that act against the clotting factor. Developing viral infections from human clotting factors.

**Research: ** **<span style="font-family: 'Times','serif'; font-size: 12pt;">Hemophilia is a blood condition that means bleeding does not stop. The bleeding occurs because the blood does not clot. Person with hemophilia can die if they don’t get treated. **

**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Additional Facts: ** <span style="color: black; font-family: 'Times','serif'; font-size: 12pt; line-height: normal; margin: 0in 0in 0pt;">Hemophilia is one of the most common bleeding disorders, in which the blood does not clot normally. A person suffering from hemophilia, when injured bleeds for a longer duration than a normally healthy individual. There are also chances of re-blooding at affected sites. The name hemophilia is derived from the Greek words, hemo meaning blood and philia meaning friend.

**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Punnett Square: **



**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Pedigree Chart: **



**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Resources: ** buzzle.com the free dictionary umm.edu