Marfans-Jordan+L.

Marfan Syndrome **Description: ** The Marfan Syndrome is a connective tissue disorder. Connective tissue provides substances and support to tendons, ligaments, and blood vessel walls. Cartilage makes up the connective tissue that is not normal. As a result, many of these structures are not as stiff as they should be. **Inheritance: ** Marfan Syndrome is caused by a defect in the gene that encodes the structure of fibrillin and the elastic fibers, a major component of connective tissue. This gene is called fibrillin-1 or FBNI. In most cases, Marfan Syndrome is inherited. The pattern is called “Automal dominate” meaning it occurs equally in men and women and can be inherited from just one parent with Marfan Syndrome.

**Symptoms: ** Marfan Syndrome affects different people in different ways. Some people have only mild symptoms while others are more severely affected. In most cases, the symptoms progress as the person ages. The body symptoms most often affected by Marfan Syndrome are; bones, eyes, heart, blood vessels, nervous systems, skin, and lungs.

**Daily Life: **

Individuals who have made a contribution to public perception of Marfans Syndrome include Flo-Hyman, Olympic silver medalist in woman’s volleyball, died suddenly at a match do to this disorder.

**Diagnosis: ** Scientist have determined that Marfan Syndrome is diagnosed by a defect in the fibrillin 1 gene or chromosome 15.

**Treatment: ** There is no cure for Marfan Syndrome. But, there is a treatment option that can minimize and prevent complications. To create one, scientist may have to identify and change the specific gene reasonable for the disorder before birth.

**Research: ** In 1991, researches found out that 1,000 mutations within the fibrillin gene. Researchers are learning more about the role fibrillin gene plays in growth and development of connective tissue.

**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Punnett Square: **



**<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Pedigree Chart: **

**<span style="color: black; font-family: 'Times New Roman','serif';">﻿ ****<span style="color: black; font-family: 'Times','serif'; font-size: 12pt;">Resources: **
 * <span style="font-family: 'Times New Roman','serif'; font-size: 11pt; line-height: 115%;">[|www.American heart. Org] **
 * <span style="color: black; font-family: 'Times New Roman','serif'; font-size: 12pt; line-height: 115%;">[|www.medicinenet.com/mardan syndrome] **