Progeria-+Brianna+Carboy

**Description:** In ninety percent of the occurrences of this disease, it is caused by a mutation on the gene that encodes the protein Lamin A. it effects the whole body resembling normal human aging. This disease rarely occurs in more than one person in a family, given that the average lifespan of a Progeria victim is only early to late teens and it can not be inherited.
 * Progeria**

**Inheritance: **  This disease is not inherited.

**Symptoms: **

· Growth failure during the first year of life · Shrunken or wrinkled face · Baldness · Loss of eyebrows or eyelashes · Short stature · Macrocephaly (large head for size of face) · Fontanelle (open soft spot) · Micrognathia (small jaw) · Dry, scaly or thin skin · Limited motion · Delayed or absent formation of teeth · Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened) · <span style="color: black; font-family: 'Times New Roman',serif;">Insulin resistant diabetes

<span style="font-family: 'Times New Roman',serif;">media type="custom" key="9495668"

**<span style="color: black; font-family: 'Times New Roman',serif;">Diagnosis: ** <span style="color: black; font-family: 'Times New Roman',serif; line-height: 14.25pt; margin-bottom: 0in;"> It is relatively easy to diagnose a person with Progeria. The symptoms make it obvious. With a single look a person can be diagnosed. Also, a test can be conducted on the gene that produces lamin A or a cardiac stress test can be conducted.

**<span style="color: black; font-family: 'Times New Roman',serif;">Treatment: ** <span style="color: black; font-family: 'Times New Roman',serif; line-height: normal; margin-bottom: 0in;">While research is being conducted, there is no known treatment or cure for Progeria.

**<span style="color: black; font-family: 'Times New Roman',serif;">Research: ** <span style="color: black; font-family: 'Times New Roman',serif; line-height: normal; margin-bottom: 0in;">Doctors have tested the IGF-1 on progeroid mice and their conditions have improved. They gained weight and began to grow hair.

**<span style="color: black; font-family: 'Times New Roman',serif;">Additional Facts: ** <span style="color: black; font-family: 'Times New Roman',serif; line-height: normal; margin-bottom: 0in;">The cause of death with this disease is usually stroke or heart failure. Some patients with Progeria can live to be in their thirties. <span style="color: black; font-family: 'Times New Roman',serif; line-height: normal; margin-bottom: 0in;">The Lamin A protein is thought to control nuclear stability, chromatin structure and gene expression.

There is no punnett square, it is not inherited.
 * Punnett square:**

There is no pedigree chart, it is not inherited.
 * Pedigree chart:**

**<span style="color: black; font-family: 'Times New Roman',serif; font-size: 11pt; line-height: 115%;">Resources: **

<span style="color: blue; font-family: Arial,sans-serif; font-size: 11pt; line-height: 115%;">Pub Med Health <span style="color: black; font-family: 'Times New Roman',serif; font-size: 11pt; line-height: 115%;">Nelson Textbook of Pediatrics edition:18th Chapter: 90